Higher-Order Disease Interactions in Multimorbidity Measurement: Marginal Benefit Over Additive Disease Summation
We present novel insights into simultaneous higher-order disease interactions for potential integration into multimorbidity measurement. Incorporating 2-way disease interactions for the top 10 most prevalent and impactful conditions showed a minimal improvement in model fit. A more precise multimorbidity index may incorporate both the main effects of diseases and their significant interactions.
Authors
- Chi‐Hong Tseng (ORCID: https://orcid.org/0000-0002-2549-6167)
- Melissa Y. Wei (ORCID: https://orcid.org/0000-0001-5093-6040)
- Ashley J Kang
Institutions
- Los Angeles County Department of Health Services (US)
- University of California, Los Angeles (US)
- Center for the Study of Healthcare Provider Behavior (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1093/gerona/glae282
- Citations
- 2
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Institutes of Health
- National Institute on Aging