Type 1 Diabetes and Cataracts: Investigating Mediating Effects of Serum Metabolites Using Bidirectional Mendelian Randomization
This study provides strong evidence of a causal link between T1D and cataracts, highlighting the mediating role of specific serum metabolites. These findings underscore the importance of early detection and management of cataracts in patients with T1D and suggest potential therapeutic targets for mitigating cataract risk. Further research should focus on replicating these findings in diverse populations and exploring the underlying metabolic pathways in greater detail.
Authors
- Jin Yang (ORCID: https://orcid.org/0000-0002-3556-0046)
- Yumeng Shi
- Yankai Li
- Yi Lü (ORCID: https://orcid.org/0000-0002-0245-7392)
- Jian Qin (ORCID: https://orcid.org/0000-0001-7113-555X)
Institutions
- Sun Yat-sen University (CN)
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- Metabolites
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3390/metabo14110644
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China