Type 1 Diabetes and Cataracts: Investigating Mediating Effects of Serum Metabolites Using Bidirectional Mendelian Randomization

This study provides strong evidence of a causal link between T1D and cataracts, highlighting the mediating role of specific serum metabolites. These findings underscore the importance of early detection and management of cataracts in patients with T1D and suggest potential therapeutic targets for mitigating cataract risk. Further research should focus on replicating these findings in diverse populations and exploring the underlying metabolic pathways in greater detail.

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Publication Details

Journal
Metabolites
Published
2024-11-20
DOI
https://doi.org/10.3390/metabo14110644
Citations
2
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
1.10

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article

Type 1 Diabetes and Cataracts: Investigating Mediating Effects of Serum Metabolites Using Bidirectional Mendelian Randomization

Jin Yang, Yumeng Shi, Yankai Li, Yi Lü et al.
2 citations
Metabolites
Genetic Associations and Epidemiology
1.10
article

Type 1 Diabetes and Cataracts: Investigating Mediating Effects of Serum Metabolites Using Bidirectional Mendelian Randomization

Jin Yang, Yumeng Shi, Yankai Li, Yi Lü, Jian Qin
article en
2 citations

Abstract

This study provides strong evidence of a causal link between T1D and cataracts, highlighting the mediating role of specific serum metabolites. These findings underscore the importance of early detection and management of cataracts in patients with T1D and suggest potential therapeutic targets for mitigating cataract risk. Further research should focus on replicating these findings in diverse populations and exploring the underlying metabolic pathways in greater detail.

MetabolitesVol. 14(11)
Sun Yat-sen University (CN), Eye & ENT Hospital of Fudan University (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Good health and well-being
Openalex Percentile: Top 18%
Genetic Associations and Epidemiology
1.10
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