The Efficiency of Respiratory Support in the Early Period of Intoxication of Rabbits with the Products of Thermal Degradation of Fluoroplast-4

Inhalation intake of acylating pulmonary toxicants (phosgene and perfluoroisobutylene) leads to the formation of toxic pulmonary edema; the pharmacological approaches to its treatment are inefficient. Respiratory therapy is successfully used to treat the pulmonary edema of nontoxic genesis. Data on the efficiency of respiratory support during toxic pulmonary edema are limited. The aim of this study was to experimentally test the efficiency of protective artificial ventilation with maintenance of positive end-expiratory pressure in the early period of intoxication with the products of thermal degradation of fluoroplast-4. In the experimental study, it was established that early implementation of protective artificial ventilation with maintenance of end-expiratory pressure is an efficient approach for the correction of toxic pulmonary edema in rabbits in the early period of intoxication with the products of thermal degradation of fluoroplast-4, which have a toxic pulmonary effect. Respiratory support can be a promising approach for the treatment of toxic pulmonary edema caused by intoxication with acylating pulmonary toxicants.