Association of asthma and bronchiectasis: Mendelian randomization analyses and observational study
The MR analysis uncovered a notable genetic association between asthma and bronchiectasis, which was partially mediated by sinusitis, nasal polyps, and eosinophils. A subsequent retrospective study provided further evidence by demonstrating that bronchiectasis patients with asthma had a higher prevalence of sinusitis, nasal polyps, an elevated proportion of eosinophils, and higher eosinophil counts.
Authors
- Jiayi Wang (ORCID: https://orcid.org/0000-0001-9255-9079)
- Yue Su (ORCID: https://orcid.org/0000-0001-8705-2783)
- Rui Fan (ORCID: https://orcid.org/0000-0003-2593-6596)
- Jin‐Fu Xu (ORCID: https://orcid.org/0000-0002-8039-8973)
- Fang Jiang (ORCID: https://orcid.org/0000-0001-7805-4912)
- Hao Qian (ORCID: https://orcid.org/0000-0001-7808-6009)
- Jiayan Xu (ORCID: https://orcid.org/0000-0001-9897-5778)
- Jia-Wei Yang
- Wei-Jun Cao
Institutions
- Tongji University (CN)
- Chinese University of Hong Kong (HK)
- Fudan University (CN)
- Huadong Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s12931-024-03034-3
- Citations
- 1
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- Science and Technology Commission of Shanghai Municipality