Mineralized collagen plywood contributes to bone autograft performance
Autologous bone (AB) is the gold standard for bone-replacement surgeries<sup>1</sup>, despite its limited availability and the need for an extra surgical site. Traditionally, competitive biomaterials for bone repair have focused on mimicking the mineral aspect of bone, as evidenced by the widespread clinical use of bioactive ceramics<sup>2</sup>. However, AB also exhibits hierarchical organic structures that might substantially affect bone regeneration. Here, using a range of cell-free biomimetic-collagen-based materials in murine and ovine bone-defect models, we demonstrate that a hierarchical hybrid microstructure-specifically, the twisted plywood pattern of collagen and its association with poorly crystallized bioapatite-favourably influences bone regeneration. Our study shows that the most structurally biomimetic material has the potential to stimulate bone growth, highlighting the pivotal role of physicochemical properties in supporting bone formation and offering promising prospects as a competitive bone-graft material.
Authors
- Marie‐Laure Colombier (ORCID: https://orcid.org/0000-0001-5127-2880)
- Nadine Nassif (ORCID: https://orcid.org/0000-0002-4094-4909)
- L. Behr
- Thibaut Divoux (ORCID: https://orcid.org/0000-0002-6777-5084)
- Sébastien Manneville (ORCID: https://orcid.org/0000-0002-4706-885X)
- Anne Meddahi‐Pellé (ORCID: https://orcid.org/0000-0002-4868-2093)
- Graciela Pavon‐Djavid (ORCID: https://orcid.org/0000-0001-5819-1071)
- Marc Robin
- Gabriel Castillo Dalí
- Saffar Jl (ORCID: https://orcid.org/0000-0001-6288-9325)
- Yan Wang (ORCID: https://orcid.org/0000-0001-9417-0550)
- Laurence Choudat (ORCID: https://orcid.org/0000-0002-4759-2467)
- Marie‐Madeleine Giraud‐Guille
- Delphine Cardi
- Fannie Baudimont
- Elodie Mouloungui
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Universitaire de France (FR)
- Collège de France (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Laboratory Orofacial Pathologies, Imaging and Biotherapies (FR)
- Instituto de Ciencia de Materiales de Sevilla (ES)
- Laboratoire de Physique de l'ENS de Lyon (FR)
- Chimie de la Matière Condensée de Paris (FR)
- Laboratoire de Recherche Vasculaire Translationnelle (FR)
- Hôpital Bichat-Claude-Bernard (FR)
Publication Details
- Journal
- Nature
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1038/s41586-024-08208-z
- Citations
- 94
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 17.34
Funders
- European Synchrotron Radiation Facility
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Fondation du Collège de France
- Fondation EDF
- Société d'Accélération du Transfert de Technologies
- Université de Paris