Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept
The introduced optimization approaches allow for mixed- or multi-RBE optimization in CIRT through the selection of RBE models independently for each region of interest. This capability addresses challenges of adhering to multiple RBE frameworks and proposes an advanced solution for tailored patient treatment plans.
Authors
- Semi Harrabi (ORCID: https://orcid.org/0000-0003-1195-7150)
- Peter Lysakovski
- Thomas Tessonnier (ORCID: https://orcid.org/0000-0002-8919-4299)
- Giuseppe Magro (ORCID: https://orcid.org/0000-0001-7140-8642)
- Amir Abdollahi (ORCID: https://orcid.org/0000-0002-8016-5897)
- Jürgen Debus (ORCID: https://orcid.org/0000-0002-6411-4811)
- Andrea Mairani (ORCID: https://orcid.org/0000-0001-6669-7064)
- Thomas Haberer
- Aaron Paul Osburg
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heidelberger Institut für Radioonkologie (DE)
- National Center for Oncological Hadrontherapy (IT)
- National Center for Tumor Diseases (DE)
Publication Details
- Journal
- Physics and Imaging in Radiation Oncology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.phro.2024.100679
- Citations
- 2
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Bundesministerium für Bildung und Forschung