Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041
A new indigotin alkaloid, named talarindigotin A (<b>1</b>), along with the analogue 5H, 6H-quinindolin-11-one (<b>2</b>) were isolated from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound <b>1</b> showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC<sub>50</sub> values ranging from 2.08 to 4.58 μM.
Authors
- Yuhua Long (ORCID: https://orcid.org/0000-0001-9913-1008)
- Zirong Lin
- Lingling Liu (ORCID: https://orcid.org/0000-0002-3315-3404)
- Zhe Zhou (ORCID: https://orcid.org/0000-0003-4616-0467)
- H. Y. Zeng
- Jia-Lin Li
Institutions
- South China Normal University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1080/10286020.2024.2428228
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China