Empagliflozin prevents TNF-α induced endothelial dysfunction under flow -the potential involvement of calcium and sodium-hydrogen exchanger
EMPA mitigates increased ROS production and impaired NO bioavailability in TNF-α stimulated cells under flow. The anti-oxidative effect of EMPA is mediated by the decreased intracellular [Ca<sup>2+</sup>] following NHE1 inhibition.
Authors
- Benedikt Preckel (ORCID: https://orcid.org/0000-0003-4412-9183)
- Nina C. Weber (ORCID: https://orcid.org/0000-0003-1111-9042)
- Olivia C. Klatt (ORCID: https://orcid.org/0009-0008-3771-6893)
- Coert J. Zuurbier (ORCID: https://orcid.org/0000-0001-8361-2448)
- Markus W. Hollmann (ORCID: https://orcid.org/0000-0001-8248-0244)
- Xiaoling Li
- Mengnan Wang (ORCID: https://orcid.org/0000-0003-0081-6264)
- Marlene Wolfsgruber
Institutions
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.ejphar.2024.177147
- Citations
- 8
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- China Scholarship Council