Discordance between creatinine and cystatin C-based estimation of glomerular filtration rate (eGFR) in solid organ transplant recipients
Cystatin C incorporation leads to markedly negative biases between eGFR estimates in patients with solid organ transplant, implying lack of applicability of eGFR<sub>cys</sub> or GFR<sub>cr-cys</sub> in the transplant setting. This highlights the dependency of patient characteristics on equation performance and the need to consider confounding factors in interpretation and utilization of cystatin C based equations.
Authors
- Mary Kathryn Bohn (ORCID: https://orcid.org/0000-0003-3464-5221)
- Rajeevan Selvaratnam (ORCID: https://orcid.org/0000-0003-4457-616X)
- Davor Brinc (ORCID: https://orcid.org/0000-0003-4471-8965)
- Meshach Asare-Werehene
- Felix Leung (ORCID: https://orcid.org/0000-0001-8166-3794)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Sinai Health System (CA)
Publication Details
- Journal
- Clinical Biochemistry
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.clinbiochem.2024.110853
- Citations
- 1
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- University Health Network