Circulating extracellular vesicles in sera of chronic patients as a method for determining active parasitism in Chagas disease
Our results confirm the usefulness of circulating EVs and their immunocomplexes as markers of metabolically active T. cruzi in chronic infections without detectable parasitaemia, as well as their efficacy in confirming vertical transmission and in cases of inconclusive diagnostic tests.
Authors
- Luís Alcalá
- Antonio Osuna (ORCID: https://orcid.org/0000-0002-3818-1471)
- José Miguel Sahuquillo-Arce (ORCID: https://orcid.org/0000-0002-0139-8271)
- Mercedes Gómez-Samblás (ORCID: https://orcid.org/0000-0003-4801-528X)
- María Trelis (ORCID: https://orcid.org/0000-0002-5977-3337)
- Luis Miguel De Pablos (ORCID: https://orcid.org/0000-0001-8940-2919)
- Alexa Prescilla-Ledezma (ORCID: https://orcid.org/0000-0001-5324-6344)
- Eva Muñoz (ORCID: https://orcid.org/0000-0002-0177-0037)
- Noelia Lozano
Institutions
- Universidad de Panamá (PA)
- Universitat de València (ES)
- Universidad de Granada (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1371/journal.pntd.0012356
- Citations
- 5
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Fundación Ramón Areces