Cerbera odollam fruit extracts enhance anti-cancer activity of sorafenib in HCT116 and HepG2 cells
Utilizing sub-IC<sub>50</sub> concentrations of COEtOAc or CODCM in combination with sorafenib can enhance targeted anticancer effects beyond those achieved with single-agent treatments, while mitigating opposing side effects. Future research will focus on extracting and characterizing active constituents, especially cardiac glycosides, to enhance the therapeutic potential of anticancer compounds derived from toxic plants.
Authors
- Pranee Nangngam (ORCID: https://orcid.org/0000-0002-3867-2174)
- Zhi‐Hong Jiang (ORCID: https://orcid.org/0000-0002-7956-2481)
- Piyarat Srisawang (ORCID: https://orcid.org/0000-0002-0948-8239)
- Apirath Wangteeraprasert (ORCID: https://orcid.org/0000-0001-7592-5436)
- Supawadee Parhira (ORCID: https://orcid.org/0000-0002-2077-5888)
- Dumrongsak Pekthong (ORCID: https://orcid.org/0000-0001-8965-3435)
- Julintorn Somran (ORCID: https://orcid.org/0000-0001-7158-0928)
- Orakot Simanurak (ORCID: https://orcid.org/0000-0002-7976-6767)
- Li‐Ping Bai (ORCID: https://orcid.org/0000-0002-2806-6883)
- Khemmachat Pansooksan
Institutions
- Macau University of Science and Technology (MO)
- Naresuan University (TH)
Publication Details
- Journal
- Chinese Herbal Medicines
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.chmed.2024.11.007
- Citations
- 3
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- Naresuan University
- Agricultural Research Development Agency
- Faculty of Medical Science, Naresuan University