ACROPath Oligometastases: The American College of Radiation Oncology Clinical Pathway

Radiation oncology is among the most data-driven specialties in medicine. Recently, a wealth of peer-reviewed data has been published supporting the treatment of oligometastatic malignancies, demonstrating improved survival with metastasis-directed therapy, such as stereotactic body radiation therapy (SBRT), when combined with appropriate patient selection and treatment. However, there are currently few, if any, established guidelines that synthesize the abundance of data specific to radiotherapy into a single, easily accessed resource for clinicians. ACROPath® is a major initiative of the American College of Radiation Oncology (ACRO) that aims to present aggregated clinical pathway data in a highly usable format that is readily accessible to clinicians at the point of care in real time. The oligometastases pathway is the first published algorithm in this collection, with additional pathways anticipated in future publications. Clinical radiation oncologists with expertise in the treatment and management of oligometastatic disease were recruited from across ACRO's diverse membership, including both academic and private practice physicians, to ensure a broad-based experience and insight. Individual participants were assigned subsections of the pathway for guideline development, and then, each subsection was presented to the full group for evaluation and consensus development based on published data. Rather than presenting an unstructured set of treatment options, as is common in other treatment guidelines, this initiative aimed to categorize appropriate treatments based on published clinical evidence in a hierarchy further ranked by efficacy, toxicity, and cost. Based on these strata, treatment recommendations were collated and grouped into three rank categories (gold, silver, or bronze) to denote the degree of applicability. The team assembled an interactive document that will eventually be available online, and it is summarized in detail here. Recommendations are grouped both by the anatomic site of metastasis and by the primary tumor type, recognizing that original histology might impact the treatment differently in different anatomic locations. After a review of available published clinical evidence, the committee reached a consensus on all recommendations presented, categorizing each option as gold, silver, or bronze to guide clinicians appropriately. This first iteration of ACROPath® Oligometastases represents one of the few comprehensive clinical decision support tools available for managing patients with limited metastatic disease. It presents available data in a highly accessible, easily used reference, which will be formally reviewed and updated by the committee as frequently as emerging data requires, likely at six- to 12-month intervals.