Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects
ADORA3 expression varies considerably in HCC or CCA, ranging from high to absent receptor detection. This observation might help to identify patients for clinical studies. Additionally, Namodenoson's epigenetic modulating activity suggests epigenetic drugs as promising candidates for combination treatment.
Authors
- Michael Bitzer (ORCID: https://orcid.org/0000-0002-4463-8263)
- Veit Scheble
- Sven Nahnsen (ORCID: https://orcid.org/0000-0002-4375-0691)
- Manfred Claassen (ORCID: https://orcid.org/0000-0002-4583-9083)
- Pascal Woelffing
- Christian M. Schürch (ORCID: https://orcid.org/0000-0002-1792-1768)
- Lauriane Blukacz (ORCID: https://orcid.org/0000-0002-1144-4024)
- Markus H. Heim (ORCID: https://orcid.org/0000-0002-7523-4894)
- Sepideh Babaei (ORCID: https://orcid.org/0000-0002-5957-6907)
- Yizheng Zhang (ORCID: https://orcid.org/0009-0003-4891-950X)
- Stefan Czemmel (ORCID: https://orcid.org/0000-0002-9490-286X)
- Sandro Nuciforo (ORCID: https://orcid.org/0000-0002-1863-1869)
- Nisar P. Malek (ORCID: https://orcid.org/0000-0002-9916-4608)
- Markus F. Templin (ORCID: https://orcid.org/0000-0002-6569-6489)
- Steffen Lemke (ORCID: https://orcid.org/0009-0009-8121-082X)
- Aaron Stahl (ORCID: https://orcid.org/0000-0003-3616-9564)
- Irene González-Menéndez (ORCID: https://orcid.org/0000-0003-3608-4704)
- Daniel Dauch (ORCID: https://orcid.org/0000-0002-9805-5784)
- Hans Bösmüller (ORCID: https://orcid.org/0000-0002-7515-435X)
- Marie‐Anne Meier
- Louise Kaldjob-Heinrich
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
- Natural and Medical Sciences Institute (DE)
- Guided Therapeutics (United States) (US)
- University of Tübingen (DE)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.gastha.2024.11.006
- Citations
- 4
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung