Quantitative Imaging of Regional Cerebral Protein Synthesis in Clinical Alzheimer's Disease by [11C]Leucine PET
In summary, this first human study assessing regional protein synthesis with [<sup>11</sup>C]leucine in AD has demonstrated where the sources of variance in measurements of cerebral protein synthesis may arise, along with the potential magnitude of this variance. This study also indicates that there is a tendency towards impairment of rCPS in patients with Alzheimer's disease, which requires further investigation including possible partial volume effects due to atrophy.
Authors
- Rainer Hinz (ORCID: https://orcid.org/0000-0002-7808-9207)
- Hervé Boutin (ORCID: https://orcid.org/0000-0002-0029-5246)
- Karl Herholz (ORCID: https://orcid.org/0000-0002-8658-0151)
- J. C. Thompson (ORCID: https://orcid.org/0000-0002-7512-7570)
- Jamil Gregory
- Adam McMahon (ORCID: https://orcid.org/0000-0002-6130-2008)
- Matthew Jones (ORCID: https://orcid.org/0000-0002-7979-1954)
- Christine A. Parker
Institutions
- Université de Tours (FR)
- Inserm (FR)
- GlaxoSmithKline (United Kingdom) (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Greater Manchester STEM Centre (GB)
- University of Salford (GB)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1007/s11307-024-01965-3
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- GlaxoSmithKline
- Wayne State University