Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome

Poor diet, gut dysbiosis, and systemic inflammation constitute a gut-heart axis (GHA) that may affect heart failure with preserved ejection fraction. Clinical scale models to interrogate this axis are limited. Here, we show the full extent of the GHA-gut barrier function loss, systemic and microvascular inflammation, and its colocalization with apoptosis (left atrium) and hypertrophy (left ventricle). Gut barrier function primacy in regulating the GHA is supported by a synbiotic intervention that shuts down gut epithelial permeability, markedly decreasing systemic inflammation and, remarkably, cardiac structural changes in left heart chambers. These data support a new paradigm for targeting heart failure with preserved ejection fraction via the GHA.

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Publication Details

Journal
JACC Basic to Translational Science
Published
2024-11-20
DOI
https://doi.org/10.1016/j.jacbts.2024.09.004
Citations
13
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
5.23

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article

Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome

Fatma Koç, Noel M. Caplice, Aoife N. O’Donovan, Florence M. Herisson et al.
13 citations
JACC Basic to Translational Science
Cardiovascular Function and Risk Factors
5.23
article

Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome

Fatma Koç, Noel M. Caplice, Aoife N. O’Donovan, Florence M. Herisson, Kavita Karnik, R. Paul Ross, Maria Antonia Llopis-Grimalt, Ieva Laurie, Catherine Stanton, Kirstie Canene‐Adams, Gaston Cluzel
article en
13 citations

Abstract

Poor diet, gut dysbiosis, and systemic inflammation constitute a gut-heart axis (GHA) that may affect heart failure with preserved ejection fraction. Clinical scale models to interrogate this axis are limited. Here, we show the full extent of the GHA-gut barrier function loss, systemic and microvascular inflammation, and its colocalization with apoptosis (left atrium) and hypertrophy (left ventricle). Gut barrier function primacy in regulating the GHA is supported by a synbiotic intervention that shuts down gut epithelial permeability, markedly decreasing systemic inflammation and, remarkably, cardiac structural changes in left heart chambers. These data support a new paradigm for targeting heart failure with preserved ejection fraction via the GHA.

JACC Basic to Translational ScienceVol. 10(1)
Teagasc - The Irish Agriculture and Food Development Authority (IE), University College Cork (IE), Tate & Lyle (United Kingdom) (GB), APC Microbiome Institute (IE)
Science Foundation Ireland, Teagasc, University College Cork
Good health and well-being
Openalex Percentile: Top 4%
Cardiovascular Function and Risk Factors
5.23
DOIOpen Access PDFOpenAlex
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Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome — Fatma Koç, Noel M. Caplice, et al. · JACC Basic to Translational Science (2024) | TGRS Research Map | TGRS