Dosimetric and biological impact of activity extravasation of radiopharmaceuticals in PET imaging
The likelihood of epidermal erythema resulting from extravasation during PET imaging is low, as the simulated absorbed doses to the epidermis remain below the thresholds that trigger such effects. Moreover, the organ-level absorbed doses were found to be clinically insignificant across various simulated organs. The minimal DNA damage at the extravasation site suggests that long-term harm, such as radiation-induced carcinogenesis, is highly unlikely.
Authors
- Dustin Osborne (ORCID: https://orcid.org/0000-0003-1324-5464)
- John J. Sunderland (ORCID: https://orcid.org/0000-0002-0891-1234)
- Greeshma Agasthya (ORCID: https://orcid.org/0000-0002-2301-5964)
- Ashok Tiwari (ORCID: https://orcid.org/0000-0003-2082-2901)
- Anuj Kapadia (ORCID: https://orcid.org/0000-0003-2755-4495)
- Matthew Andriotty
Institutions
- University of Iowa (US)
- Oak Ridge National Laboratory (US)
- Georgia Institute of Technology (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- Medical Physics
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1002/mp.17520
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- U.S. Department of Energy