Predicting survival, neurotoxicity and response in B-cell lymphoma patients treated with CAR-T therapy using an imaging features-based model
This study successfully integrates imaging features and clinical variables to predict outcomes in R/R B-cell lymphoma patients undergoing CAR-T. Notably, the identified MTV<sub>total</sub> cut-off effectively stratifies patients, as evidenced by significant differences in OS and PFS. Additionally, the predictive models for neurotoxicity and CAR-T response show promising accuracy. This comprehensive approach holds promise for risk stratification and personalized treatment strategies which may become a helpful tool for optimizing CAR-T outcomes in R/R lymphoma patients.
Authors
- Manuel Guerreiro (ORCID: https://orcid.org/0000-0001-5978-2578)
- Rosa Dosdá
- Ana Benzaquén (ORCID: https://orcid.org/0000-0003-4015-0831)
- Ángel Alberich‐Bayarri (ORCID: https://orcid.org/0000-0002-5932-2392)
- Blanca Ferrer Lores (ORCID: https://orcid.org/0000-0001-9452-7310)
- Ana Jiménez-Pastor (ORCID: https://orcid.org/0000-0002-0978-9429)
- Jaime Sanz (ORCID: https://orcid.org/0000-0001-6934-4619)
- Alicia Serrano‐Alcalá (ORCID: https://orcid.org/0000-0002-3392-4336)
- Fuensanta Bellvís–Bataller
- Rafael Hernani (ORCID: https://orcid.org/0000-0003-1043-8076)
- Almudena Fuster-Matanzo (ORCID: https://orcid.org/0000-0001-8667-4011)
- Aitana Balaguer‐Roselló (ORCID: https://orcid.org/0000-0003-1633-2918)
- José Luís Piñana (ORCID: https://orcid.org/0000-0001-8533-2562)
- María José Terol (ORCID: https://orcid.org/0000-0002-9467-932X)
- Luis Martí‐Bonmatí (ORCID: https://orcid.org/0000-0002-8234-010X)
- Alejandra Estepa‐Fernández (ORCID: https://orcid.org/0000-0002-1295-6304)
- Glen J. Weiss (ORCID: https://orcid.org/0000-0002-6067-597X)
- Laura Ventura (ORCID: https://orcid.org/0000-0001-7322-998X)
- Ana Saus-Carreres
- Alfonso Ortiz-Algarra
- Ana Belén Teruel
- Alfonso Picó-Peris
- Pablo Sopena‐Novales
- Juan Pedro Fernández
Institutions
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Quantitative BioSciences (US)
- Universitat Rovira i Virgili (ES)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s13550-024-01172-9
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Gilead Sciences
- Gilead Foundation