Design, Synthesis, and Insecticidal Activity of Novel <i>meta</i>-Diamide Compounds Bearing a Phthalimide as a Potential GABA Receptor Antagonist
In pursuit of potent and environmentally benign insecticides targeting the γ-aminobutyric acid (GABA) receptor, a series of novel meta-diamide compounds bearing a phthalimide were rationally designed and synthesized. Bioassay studies revealed that most of the target compounds exhibited promising larvicidal activity against <i>Mythimna separata</i> (<i>M. separata</i>) and <i>Plutella xylostella</i> (<i>P. xylostella</i>). Notably, the most active compound <b>N</b><sub><b>15</b></sub> displayed exceptional potency with LC<sub>50</sub> values of 3.82 and 3.42 mg·L<sup>-1</sup> against <i>M. separata</i> and <i>P. xylostella</i>, respectively. Electrophysiological studies using <i>Xenopus oocytes</i> confirmed that compound <b>N</b><sub><b>15</b></sub> exerted its insecticidal activity by targeting the GABA receptors.
Authors
- Xusheng Shao (ORCID: https://orcid.org/0000-0002-2579-7533)
- Chunqing Zhao (ORCID: https://orcid.org/0000-0002-7942-488X)
- Qiu‐Tang Huang (ORCID: https://orcid.org/0000-0001-7123-905X)
- Lu Zhang (ORCID: https://orcid.org/0000-0003-1039-0367)
- Zhong Li (ORCID: https://orcid.org/0000-0001-6665-5040)
- Zhenguo Zhang (ORCID: https://orcid.org/0000-0001-7872-4947)
Institutions
- Nanjing Agricultural University (CN)
- East China University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1021/acs.jafc.4c05418
- Citations
- 6
- Primary Topic
- Insect and Pesticide Research
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- Shanghai Municipal Education Commission
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities