Detection of methotrexate molecules in human plasma by SERS method
This study demonstrates the possibility of using the SERS method to detect methotrexate (MTX) molecules in the blood plasma of patients in concentrations up to 10<sup>-6</sup> M. The paper performs investigation for samples from patients who took the drug at different doses. Borosilicate glasses coated with silver nanoparticles were used as the surface. We analyzed the differences between the spectra of patients after taking medication and healthy volunteers without taking medication. The characteristic maxima of methotrexate were determined.
Authors
- Ivan Lyatun (ORCID: https://orcid.org/0000-0002-4988-8077)
- Ilia Samusev (ORCID: https://orcid.org/0000-0001-5026-7510)
- Elizaveta Demishkevich (ORCID: https://orcid.org/0000-0001-9481-1549)
- Alexander Zozulya
- Denis Evtifeev
- Vladimir Rafalskiy (ORCID: https://orcid.org/0000-0002-2503-9580)
- Anna Kundalevich (ORCID: https://orcid.org/0000-0001-7428-6441)
- Зюбин Андрей Юрьевич (ORCID: https://orcid.org/0000-0002-9766-1408)
- S. A. Doktorova (ORCID: https://orcid.org/0000-0001-5858-7877)
Institutions
- Immanuel Kant Baltic Federal University (RU)
Publication Details
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1117/12.3036059
- Primary Topic
- Diverse Scientific Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00