Analysis of Concordance Between Next-Generation Sequencing Assessment of Microsatellite Instability and Immunohistochemistry-Mismatch Repair From Solid Tumors
This study demonstrates that NGS-MSI is noninferior to IHC-MMR and can identify MSI-H tumors that IHC-MMR is unable to detect and conversely IHC-MMR can identify MMRd tumors that NGS-MSI misses.
Authors
- Robert Morris (ORCID: https://orcid.org/0000-0003-1615-5915)
- Evi Abada (ORCID: https://orcid.org/0000-0001-5061-2687)
- Anthony N. Karnezis (ORCID: https://orcid.org/0000-0003-2924-1126)
- Fadi Zaiem (ORCID: https://orcid.org/0009-0002-9252-4276)
- Shuanzeng Wei (ORCID: https://orcid.org/0000-0002-0441-6973)
- Logan Corey (ORCID: https://orcid.org/0000-0003-2880-7546)
- Leana M. Elbashir
- Subhayu Bandyopadhyay (ORCID: https://orcid.org/0000-0003-1626-6543)
- Jaclyn F. Hechtman (ORCID: https://orcid.org/0000-0003-2645-0985)
- Harris B. Krause (ORCID: https://orcid.org/0000-0003-3481-8364)
- Milan M. Radovich (ORCID: https://orcid.org/0000-0001-9667-156X)
- John Wallbillich (ORCID: https://orcid.org/0000-0001-5913-8088)
- Jeffrey Swensen (ORCID: https://orcid.org/0000-0002-8204-4220)
- Matthew James Oberley (ORCID: https://orcid.org/0000-0001-6419-2513)
- Jim Abraham (ORCID: https://orcid.org/0000-0001-5038-1735)
- Rouba-Ali Fehmi (ORCID: https://orcid.org/0009-0003-0642-535X)
- M. Ruhul Quddus (ORCID: https://orcid.org/0000-0002-1371-9095)
- George W. Sledge (ORCID: https://orcid.org/0000-0003-0297-0775)
- Pashtoon Murtaza Kasi (ORCID: https://orcid.org/0000-0002-5169-7085)
- Joanne Xiu (ORCID: https://orcid.org/0000-0001-8744-5827)
- David B. Spetzler (ORCID: https://orcid.org/0000-0002-9531-0970)
- Mira Kheil (ORCID: https://orcid.org/0000-0001-7426-5923)
- Thomas J. Herzog (ORCID: https://orcid.org/0000-0002-4584-8908)
- Andrew Elliott (ORCID: https://orcid.org/0009-0001-9302-8189)
- David Bryant
- Emmanuel S. Antonarakis (ORCID: https://orcid.org/0000-0003-0031-9655)
Institutions
- Fox Chase Cancer Center (US)
- University of Minnesota (US)
- Wayne State University (US)
- Cornell University (US)
- Brown University (US)
- University of Michigan (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Presbyterian Hospital (US)
- Caris Life Sciences (United States) (US)
- University of California Davis Medical Center (US)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1200/po.23.00648
- Citations
- 15
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.37