Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics
We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared with interpretation based on variant allele fraction only.
Authors
- Joseph C. Van Amburg (ORCID: https://orcid.org/0000-0002-1410-6995)
- P. Brent Ferrell (ORCID: https://orcid.org/0000-0003-1140-9154)
- Alexander G. Bick (ORCID: https://orcid.org/0000-0001-5824-9595)
- Taralynn Mack (ORCID: https://orcid.org/0000-0003-1043-2950)
- Angela Jones (ORCID: https://orcid.org/0000-0002-1565-4360)
- Yash Pershad (ORCID: https://orcid.org/0000-0002-2282-1403)
- Michael Robert Savona (ORCID: https://orcid.org/0000-0003-3763-5504)
- J. Brett Heimlich (ORCID: https://orcid.org/0000-0003-2812-5326)
- Alyssa Parker (ORCID: https://orcid.org/0000-0002-6632-7458)
- Nicole A. Mickels
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Blood
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1182/blood.2024026555
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91