Successful Allogeneic Hematopoietic Stem Cell Transplantation for Nodal Epstein-Barr Virus-positive T/NK-cell Lymphoma
Nodal Epstein-Barr virus-positive T/NK-cell lymphoma (EB-nTNKL) is an extremely rare disease characterized by an aggressive clinical course and poor prognosis, for which treatment strategies have not yet been established. We herein report a young man with EB-nTNKL. Although initial chemotherapies, including L-asparaginase, failed to produce a good response, subsequent myeloablative allogeneic hematopoietic stem cell transplantation (alloHSCT) resulted in favorable disease control and a long-term disease-free survival. The prompt performance of alloHSCT using an available donor source at that time, regardless of whether or not the initial chemotherapy was effective, could be critical to saving patients with this otherwise fatal disease.
Authors
- Naoya Morota
- Shunsuke Hatta (ORCID: https://orcid.org/0000-0002-7804-5538)
- Ryo Nakagawa (ORCID: https://orcid.org/0000-0001-5367-6731)
- Ryo Ichinohasama
- Satoshi Ichikawa (ORCID: https://orcid.org/0000-0003-3163-7197)
- Akihisa Kawajiri (ORCID: https://orcid.org/0000-0002-5989-7786)
- Noriko Fukuhara (ORCID: https://orcid.org/0000-0003-2682-2179)
- Kyoko Inokura
- Yasushi Onishi (ORCID: https://orcid.org/0000-0003-0032-6994)
- Hideo Harigae (ORCID: https://orcid.org/0000-0003-4849-7442)
- Hisayuki Yokoyama (ORCID: https://orcid.org/0000-0001-7658-0687)
- Hiroaki Abe
- Yuna Katsuoka
- Koichi Onodera
Institutions
- Tohoku University Hospital (JP)
- Sendai Medical Center (JP)
- Yamagata University Hospital (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2024-11-20
- DOI
- https://doi.org/10.2169/internalmedicine.4672-24
- Citations
- 2
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.48