Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite
In this small trial, GA2 was associated with a favorable immune induction profile and protective efficacy, findings that warrant further evaluation. (Funded by the Bontius Foundation; ClinicalTrials.gov number, NCT04577066.).
Authors
- Jacqueline J. Janse (ORCID: https://orcid.org/0000-0003-4884-5881)
- Wouter Graumans (ORCID: https://orcid.org/0000-0003-3952-6491)
- Séverine Chevalley‐Maurel (ORCID: https://orcid.org/0000-0002-2048-540X)
- Matthew B. B. McCall (ORCID: https://orcid.org/0000-0002-5738-1401)
- Blandine Franke‐Fayard
- Teun Bousema (ORCID: https://orcid.org/0000-0003-2666-094X)
- Rajagopal Murugan
- Emma L. Houlder (ORCID: https://orcid.org/0000-0003-0448-6055)
- Eleni G. Iliopoulou
- Fiona J. A. Geurten
- Benjamin Mordmüller (ORCID: https://orcid.org/0000-0001-9101-2768)
- Chris J. Janse (ORCID: https://orcid.org/0000-0002-6410-6205)
- Emil Colstrup (ORCID: https://orcid.org/0000-0002-3942-712X)
- Meta Roestenberg (ORCID: https://orcid.org/0000-0002-5052-2830)
- Els Wessels (ORCID: https://orcid.org/0000-0002-6707-2311)
- Geert V.T. Roozen (ORCID: https://orcid.org/0000-0002-3979-4616)
- Jan Pieter R. Koopman (ORCID: https://orcid.org/0000-0003-1335-9402)
- Marga van de Vegte‐Bolmer (ORCID: https://orcid.org/0000-0002-4830-7840)
- Olivia A.C. Lamers
- Geert-Jan van Gemert
- Helena M. de Bes-Roeleveld
- Thabitha R Stoter
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1056/nejmoa2313892
- Citations
- 35
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 19.00
Funders
- QIMR Berghofer Medical Research Institute
- Bontius Stichting