Population pharmacokinetics of unfractionated heparin and multivariable analysis of activated clotting time in patients undergoing radiofrequency ablation of atrial fibrillation
This study presents the first population PK-PD model characterizing the relationship between UFH doses and ACT during RFCA, along with multivariable analysis. Additionally, predictive calculators for ACT15 and UFH dose based on patient and procedural characteristics were developed, enhancing personalized anticoagulation management during RFCA.
Authors
- Céline Konecki (ORCID: https://orcid.org/0000-0002-6214-1613)
- Laurent Faroux (ORCID: https://orcid.org/0000-0003-2161-4653)
- François Lesaffre (ORCID: https://orcid.org/0000-0003-1174-1691)
- Zoubir Djerada (ORCID: https://orcid.org/0000-0002-4022-7889)
- Florine Dubuisson (ORCID: https://orcid.org/0000-0003-1425-6368)
- Catherine Féliu (ORCID: https://orcid.org/0000-0002-3928-8908)
- Sophie Guillou
- Moad Labdaoui
Institutions
- Centre Hospitalier Universitaire de Reims (FR)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.biopha.2024.117700
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.21