Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations
This study demonstrates that high concentrations of PS-MPs induce time-dependent cytotoxicity, oxidative stress, and alterations in the TCA cycle, as well as in folate, amino acid, and energy metabolism. These findings highlight the need for further research to clarify the full impact of MP contamination on pregnancy and its implications for future generations.
Authors
- Thiago Mendonça de Aquino (ORCID: https://orcid.org/0000-0001-9138-8466)
- Johann Urschitz
- Rodrigo Barbano Weingrill (ORCID: https://orcid.org/0000-0003-3699-4388)
- Stephanie Ospina‐Prieto (ORCID: https://orcid.org/0000-0002-1744-6354)
- Ana Catarina Rezende Leite (ORCID: https://orcid.org/0000-0002-3426-3357)
- Alexandre Urban Borbely (ORCID: https://orcid.org/0000-0001-6737-0901)
- Keyla Silva Nobre Pires (ORCID: https://orcid.org/0000-0001-7426-5675)
- Maiara Ingrid Cavalcante Queiroz
- Alessandre Carmo Crispim
- Edmilson Rodrigues da Rocha (ORCID: https://orcid.org/0000-0002-1358-5031)
- Iasmin Cristina Lira Cavalcante
- Julia Domingues Santos (ORCID: https://orcid.org/0000-0002-5808-3633)
- Isadora Hart Cavalcante
- Ashelley Sousa
Institutions
- University of Hawaiʻi at Mānoa (US)
- Universidade Federal de Alagoas (BR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3389/fendo.2024.1481014
- Citations
- 20
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 2.66
Funders
- National Institute for Health and Care Research
- Fundação de Amparo à Pesquisa do Estado de Alagoas
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal de Alagoas