Metabonomics analysis of decidual tissue in patients with recurrent spontaneous abortion
This study elucidates substantial metabolic disruptions in the decidual tissue of RSA patients, identifying 54 differential metabolites and 29 enriched pathways. The altered expression of ACSL4, GPX4, and IDO underscores their potential involvement in the pathogenesis of RSA. These findings provide critical insights into the metabolic mechanisms underlying RSA and suggest promising targets for diagnostic and therapeutic interventions.
Authors
- Zhihui Chen (ORCID: https://orcid.org/0000-0002-1375-8254)
- Xin Duan (ORCID: https://orcid.org/0009-0008-2931-8860)
- Jia‐Da Li (ORCID: https://orcid.org/0000-0002-4236-3518)
- Ying Long (ORCID: https://orcid.org/0000-0003-0559-3012)
- Huiling Zhu
- Hong Yin (ORCID: https://orcid.org/0000-0003-4518-4635)
- Renmei Xiong
- Hongyu Liu (ORCID: https://orcid.org/0000-0003-0359-1283)
Institutions
- Central South University (CN)
- Changsha Hospital for Maternal and Child Health Care (CN)
Publication Details
- Journal
- Journal of Reproductive Immunology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.jri.2024.104398
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00