Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome
In conclusion, we observed a phenotypic variability within family members with AEXS carrying the same <i>CYP19A1</i> microdeletion. When started early, treatment with letrozole was found to prevent the development of gynecomastia and increase adult height in one patient. In adult life, low-dose letrozole treatment resulted in improved physical strength and libido in the index patient.
Authors
- Christian Denzer (ORCID: https://orcid.org/0000-0003-0302-6161)
- Eleni Z. Giannopoulou (ORCID: https://orcid.org/0009-0000-8803-670X)
- Martin Schmidt (ORCID: https://orcid.org/0000-0003-3578-4338)
- Stefanie Zorn (ORCID: https://orcid.org/0000-0001-9375-4845)
- Alexander Kaiser (ORCID: https://orcid.org/0000-0002-9439-9176)
- Julia von Schnurbein (ORCID: https://orcid.org/0000-0001-9918-664X)
- Maki Fukami (ORCID: https://orcid.org/0000-0001-9971-4035)
- Martin Wabitsch (ORCID: https://orcid.org/0000-0001-6795-8430)
- S. Brandt (ORCID: https://orcid.org/0000-0002-8693-2647)
Institutions
- Universität Ulm (DE)
- German Center for Pediatric and Adolescent Rheumatology (DE)
- National Center For Child Health and Development (JP)
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3389/fendo.2024.1487884
- Citations
- 2
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Bundesministerium für Bildung und Forschung