Peripheral inflammatory cytokines are associated with the microstructural characteristics of the corpus callosum and prefrontal cortex as detected by magnetic resonance T1/T2 mapping in the CUMS rat model
Our study demonstrates that the microstructural abnormality of the corpus callosum is an intrinsic change that accompanies depression and also provides robust evidence that the microstructural characteristics of the corpus callosum and PFC associated with inflammatory cytokines in peripheral blood play an important role in the fundamental pathophysiological mechanism of depression.
Authors
- Yunzhu Wu (ORCID: https://orcid.org/0000-0002-4511-762X)
- Fengying Yuan
- Guidong Dai (ORCID: https://orcid.org/0000-0002-3553-4745)
- Guangxiang Chen (ORCID: https://orcid.org/0000-0001-7683-0754)
- Li Zhou (ORCID: https://orcid.org/0000-0002-3675-6665)
- Xiaofei Lu (ORCID: https://orcid.org/0000-0002-8881-7183)
- Li Wang (ORCID: https://orcid.org/0000-0003-2165-0080)
- Yurong Zheng
- Qing Yuan (ORCID: https://orcid.org/0000-0001-5421-1055)
- Maohua Wang
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Siemens Healthcare (United States) (US)
Publication Details
- Journal
- Heliyon
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e40428
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Southwest Medical University
- Health Commission of Sichuan Province