Prevalence of hybrid TLR4+M2 monocytes/macrophages in peripheral blood and lung of systemic sclerosis patients with interstitial lung disease
The presence of hybrid TLR4<sup>+</sup>M2 markers on both circulating monocytes and resident lung macrophages in SSc-ILD patients, is reported for the first time. Therefore, the detection of circulating hybrid TLR4<sup>+</sup>M2 monocytes in SSc-ILD might represent a further potential biomarker of progressive organ fibrosis, to be searched in blood samples of SSc patients.
Authors
- Rosanna Campitiello (ORCID: https://orcid.org/0009-0009-1093-1611)
- Emanuele Gotelli (ORCID: https://orcid.org/0000-0002-4732-0306)
- Stefano Soldano (ORCID: https://orcid.org/0000-0001-8796-6032)
- Vanessa Smith (ORCID: https://orcid.org/0000-0001-6271-7945)
- Alberto Sulli (ORCID: https://orcid.org/0000-0003-3674-4880)
- Maurizio Cutolo (ORCID: https://orcid.org/0000-0002-5396-0932)
- Paola Montagna (ORCID: https://orcid.org/0000-0002-0595-1484)
- Elvis Hysa (ORCID: https://orcid.org/0000-0002-6970-0983)
- Paola Contini (ORCID: https://orcid.org/0000-0001-9430-1928)
- Roberto Benelli (ORCID: https://orcid.org/0000-0002-9769-0954)
- Carol Feghali‐Bostwick (ORCID: https://orcid.org/0000-0002-6750-6407)
- Sabrina Paolino (ORCID: https://orcid.org/0000-0001-9269-5089)
- Carmen Pizzorni (ORCID: https://orcid.org/0000-0001-5125-0200)
- Marco Mora
Institutions
- Medical University of South Carolina (US)
- Ghent University Hospital (BE)
- VIB-UGent Center for Inflammation Research (BE)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1488867
- Citations
- 11
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- Fonds Wetenschappelijk Onderzoek
- Universitair Ziekenhuis Gent
- Universiteit Gent
- Vlaamse regering