Single-cell RNA sequencing reveals key molecular drivers and immune landscape in uveal melanoma: implications for targeted therapy and prognostic modeling
This study provides insights into UM metastasis via single-cell analysis, identifying C5 <i>PCOLCE</i>+ TCs as key malignancy drivers associated with oxidative phosphorylation and immune interactions. Our PTRS model highlights <i>CITED1</i> as a high-risk gene that promotes UM cell proliferation, paving the way for new prognostic models and therapeutic targets to enhance patient outcomes.
Authors
- Zhikai Xiahou
- Yue Xu (ORCID: https://orcid.org/0000-0001-6492-178X)
- Xiaofeng Zhang (ORCID: https://orcid.org/0000-0003-2738-3286)
- Wenwen Shao (ORCID: https://orcid.org/0009-0002-8888-3225)
- Zeyu Song (ORCID: https://orcid.org/0000-0003-4992-4143)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
- Beijing Sport University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1493752
- Citations
- 2
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.08