PLK2 inhibited oxidative stress and ameliorated hepatic ischemia–reperfusion injury through phosphorylating GSK3β
Overall, these findings revealed that PLK2 enhanced HO-1 expression and reduced oxidative stress damage in hepatic I/R injury, and this protective effect related to GSK3β activity.
Authors
- Xiao Tang (ORCID: https://orcid.org/0000-0003-3634-5097)
- Xiao Xu (ORCID: https://orcid.org/0000-0002-2761-2811)
- Zhoucheng Wang (ORCID: https://orcid.org/0000-0003-0381-7932)
- Shusen Zheng (ORCID: https://orcid.org/0009-0008-4640-4816)
- Xinyang Zhong (ORCID: https://orcid.org/0000-0002-4282-0125)
- Yutong Chen (ORCID: https://orcid.org/0000-0003-4234-8139)
- Kai Wang (ORCID: https://orcid.org/0000-0003-4152-8752)
- Wenwen Ge
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Red Cross Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1111/jgh.16815
- Citations
- 4
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Key Research and Development Program of China