Evaluation of Feulgen Reaction for Quantitative DNA Analysis in Oral Leukoplakia: Insights into Malignant Transformation Risk

The Feulgen reaction, combined with quantitative DNA analysis, is a valuable tool in assessing the malignant transformation risk in oral leukoplakia. The presence of aneuploidy in these lesions is significantly associated with higher dysplastic changes and an increased risk of progression to oral cancer. Further studies with larger sample sizes are recommended to validate these findings and to establish the Feulgen reaction as a standard predictive marker in clinical practice.