The Incidence of Acute Kidney Injury and Its Correlation to Serum Lactate as a Predictive Value for in Hospital Mortality in Patients with Sepsis

Abstract Background Sepsis-induced acute kidney injury (S-AKI) is a frequent outcome in hospitalized and critically ill patients, increasing the risk of developing chronic comorbidities. The recent Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) now recommends using the Sequential Organ Failure Assessment (SOFA) and the quick SOFA (qSOFA) as screening tools for sepsis and prognosis, replacing serum lactate. Objective To investigate the relationship between sepsis-associated acute kidney injury (S-AKI) and serum lactate levels as potential predictors of in-hospital mortality in hospitalized and critically ill patients. Methods This Prospective observational study study was conducted in Intensive Care Units of Ain Shams University Hospitals and research committee over 6 months from December 2022 to June 2023. 75 patients was admitted to Ain Shams intensive care unit Results Elevated lactate levels in septic patients, especially in combination with AKI, were associated with a higher incidence of organs impairment and a poorer clinical outcome. Early detection and management of elevated lactate levels and organs impairment may improve clinical outcomes in these patients. The study showed higher lactate level is accompined by more organ failure and increase mortality as in group A which had mortality rate higher than group B and C. It also correlates with long stay in ICU and hospital. Conclusion The study findings indicate that elevated lactate levels in septic patients, particularly when accompanied by AKI, are linked to a greater occurrence of more organs impairment and unfavorable clinical outcome of patients who were classified into 3 groups the first had sepsis and developed aki and high serum lactate and the second had sepsis and developed aki with normal lactate and the third group had sepsis without aki.