Impact of Hyperuricemia on Left Ventircular Function in Hypertensive Patients Presented to Ain Shams University Hospitals

Abstract Background The association between serum uric acid and cardiovascular diseases has long been recognized. Aim: The aim of study was to assess the left ventircular function in hypertensive patients with or without hyperuricemia. Patients and Methods This prospective, comparative, cross sectional study involved 300 patients coming to cardiology clinic for clinical assessment. The study was performed in the cardiology department, faculty of medicine, Ain Shams university hospital at the period from july 2022 to march 2023. Results The results of the study show a significant difference in the tie index among the three groups (Hypertension with Hyperuricemia, Hypertension without Hyperuricemia, and Control). The median tie index was highest in the Hypertension with Hyperuricemia group (0.46) followed by the Hypertension without Hyperuricemia group (0.42) and was lowest in the control group (0.37). The difference in tie index between the groups was statistically significant with a p-value of <.001. Conclusion This study reveals that hyperuricemia is widespread in our study population with systemic hypertension and both are positively correlated. Hyperuricemia was associated with LVH. Thus, the study recommends a repetitive evaluation of serum UA in all hypertensive patients. As it suggests that hyperuricemia is an early marker of increased left ventricular mass that can be used to identify a hypertensive population with cardiac TOD.