Study of Effects of Preoperative Modafinil on Recovery Profile of Morbidly Obese Patients Scheduled for Bariatric Surgery

Abstract Background Obesity is a worldwide epidemic, bariatric surgery is currently the most effective treatment for obesity with clinically significant long-term weight loss. Delayed recovery from anesthesia remains one of the biggest challenging events that involve the anesthesiologist. The time to emerge from anesthesia is affected by patient factors, anesthetic factors, duration of surgery, and painful stimulation. Modafinil is a wakefulness-inducing compound prescribed for treatment of excessive daytime sleepiness because of sleep disturbances such as OSA or narcolepsy and also used in the management of fatigue associated with different conditions including depression, cancer, or tiredness in military personnel. Aim of the Work This study was designed to study effects of preoperative Modafinil on recovery profile of morbidly obese patients scheduled for bariatric surgery. Patients and Methods It was conducted to 20 patients of both sexes, scheduled for bariatric surgeries. Cases were aged 18-60 years, ASA physical status ІІ or III with BMI 40-50 kg/m2. Results Immediate recovery time, cognitive recovery, emotional (general) status, discharge from PACU according to modified Aldrete score. There is no significant difference between the two groups in terms of demographic characteristics including age, sex, weight, ASA, surgery type and duration. Conclusion Modafinil significantly enhanced immediate post anesthesia recovery, however our results didn’t show statistical significance regarding cognitive recovery, emotional, general status and Modified Aldrete Score when compared to placebo.