The Relation of Residual Kidney Function to Post-Dialysis Fatigue

Abstract Background End-stage kidney disease (ESKD) poses intricate challenges in its management, often requiring long-term dialysis or kidney transplantation to sustain metabolic balance and fluid- electrolyte equilibrium. Despite these treatments, ESKD patients frequently experience debilitating symptoms, such as fatigue. Fatigue's prevalence is substantial in both dialysis and non-dialysis ESKD patients, impacting their daily lives and overall well-being. Residual kidney function (RKF) after dialysis initiation plays a pivotal role in influencing various health outcomes. Aim of the Work To estimate post-dialysis fatigue in chronic haemodialysis patients and its relation to residual kidney function and other associated variables. Patients and Methods The study included 70 Patients with ESKD who underwent regular HD and they were divided into 2 groups; group A (Included 35 patients who had residual kidney function) and group B (Included 35 patients who did not have residual kidney function). Results Fatigue was widespread, as indicated by FAS scores ranging from 16 to 37. Most patients experienced fatigue, with 67.1% reporting fatigue and 15.7% extreme fatigue. Although there was no significant correlation between FAS scores and RKF, RKF's role was evident in parameters like urea post-hemodialysis, influencing patient outcomes. Conclusion In conclusion, the complex interaction involving RKF and the exhaustion experienced after dialysis calls for a more profound exploration. This research brings into focus the elaborate correlation between RKF and fatigue, underscoring the diverse aspects of symptomatology in ESKD. Additional inquiries are merited to gain a more comprehensive comprehension of the variables influencing fatigue and to formulate precise interventions aimed at enhancing the quality of life for individuals with ESKD.