Evaluation of Level of Serum Immunoglobulin G, Serum Immunoglobulin M and Interleukin 10 in Hypertensive Patients

Abstract Background Hypertension is the leading risk factor for cardiovascular disease worldwide, accounting for 9.4 million deaths and 7% of global disability adjusted life years. The etiology of essential hypertension is unclear, and its mechanisms are complex Perturbations of the sympathetic and parasympathetic nervous systems, the reninangiotensin-aldosterone system, the endothelin system, genetic predisposition and environmental factors in combination or independently contribute to elevation of blood pressure (BP), and BP and/or the prohypertensive stimuli induce cardiovascular injury. Aim of the Work To measure levels of serum IgG, IgM, and IL10 in hypertensive patients as compared to healthy control. Patients and Methods This was a case-control clinical study that was conducted at the internal medicine outpatient clinic and wards of Ain Shams University hospitals on 100 subjects who weredivided into 2 groups. Results Interestingly our study showed that interleukin10 level was significantly lower in both treated and untreated hypertensives relative to control, this indicates that there is immune dysfunction in patients with essential hypertension. Additionally We found that there is significant correlation between CRP, neutrophils and hypertension among study group this confirm that inflammation plays a role in the pathogenesis of vascular disease. As expected we found the grade of progression of retinopathy andcarotid intima media thicknessincrease significantly with the degree of hypertension. Conclusion Hypertension may represent an extreme phenotype of a multifaceted and complex disease, it seems reasonable that more than one or perhaps a significant number of factors, including inflammatory and noninflammatory ones, may play a role in the pathogenesis of this syndrome. Although based on a relatively small number of patients, our results are provocative and support the importance of additional studies aimed at identifying laboratory markers that may relate to treatment resistance and ultimately to the development of new therapeutic strategies.