Thrombophilia Gene Screen Most Incriminated Factor in Portal Vein Thrombosis in Chronic Liver Disease Patients before Liver Transplantation with Protein C & S Deficiency

Abstract Background Portal vein thrombosis whether due to inherited or acquired thrombophilia is a major problem prior to liver transplantation & during surgery & post- operative requiruiring prompt diagnosis & management & thrombophilia gene screen is important to identify any inherited cause for thrombophilia as a cause for portal vein thrombosis prior or during or post-surgery or as a cause of any venous thromboembolism in liver transplantation candidate to start proper anti-coagulation when needed. Aim of the Work The aim of this study was to determine which factor in thrombophilia gene screen most incriminated in causing portal vein thrombosis in cirrhotic patients prior to liver transplantation. Patients and Methods This retrospective study included 40 chronic liver disease patient prior to liver transplantation with protein c &s deficiency,& divided into two groups where group (A) 20 patients have PVT, protein c&s deficiency & mutation in thrombophilia gene screen. And a control group (B) of 20 patients haven’t PVT & have protein c&s deficiency.& patients were collected from Ain Shams University Hospitals. Results The results of this study showed that there’s no factor in thrombophilia gene screen shown to be more incriminated in portal vein thrombosis prior to liver transplantation than the other. Conclusion It’s not settled yet which factor in thrombophilia gene screen most incriminated in portal vein thrombosis or venous thromboembolism in general, where inherited factors are considered to be low risk factors for thrombosis, yet further studies are needed with larger sample size to determine which factor is most incriminated in portal vein thrombosis prior to liver transplantation.