Effect of Transarterial Chemoembolization on Portal Venous Pressure in Patients with Hepatocellular Carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and has a poor prognosis unless treated. Transarterial chemoembolization of HCC lesions is a promising treatment option for patients who are not eligible for surgery. Objective To study the short term effect of TACE on portal venous pressure by assessing it indirectly through measuring hepatic venous pressure gradient before and after TACE procedure. Patients and Methods Our study was a Prospective cohort analysis of patients who were been referred to our IR unit (in our university hospital) diagnosed with HCC for performance of TACE at the period between January 2022 and December 2022. (21 patients). Results Our study showed that there is no short term effect of TACE on HVPG (which reflects the portal pressure). We also recommend doing a follow up measurement of HVPG after 6 months and compare it with the baseline measurements to assess the long term effect of TACE on the portal pressure. Conclusion Our study is in agreement with previous studies that there is no short term effect of TACE on HVPG (which reflects the portal pressure).