Effect of Vitamin K2 on Progression of Coronary Artery Calcification by Multislice CT Examination

Abstract Background Coronary artery disease (CAD) is associated with high mortality around the world. Dyslipidemia, hypertension, diabetes and smoking are common risk factors for CAD. Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction (AMI) and cardiovascular mortality. Vitamin K2 is thought to inhibit vascular calcification through many different mechanisms. Aim of the Work To study the effect of Vitamin K2 on coronary artery calcification using the Agatston calcium score. Patients and Methods This study was conducted on 30 patients with pre-existing CAD who were randomly assigned in a 1:1 ratio to either oral Vitamin K2 supplementation or no treatment for 6 months. Non contrast cardiac MDCT examination was done at baseline and after 6 months to detect the change in CAC score. Results 46.6 % of the cases who took the vitamin K2 (MENA Q) drug had their post 6 months follow up calcium score decreased and 53.3 % of them had their post 6 months follow up the same as the baseline, while 80 % of the patients in the control group showed an increase in their coronary artery calcium score and only 20 % of them showed no change in their coronary calcium score remaining the same as the baseline done at the start of the study. Conclusion Our study confirms that by using the CAC Agatston score, Vitamin K2 can have a role in decreasing the progression of coronary artery calcification.