Endoscopic versus Histopathological Diagnosis of Pan-gastritis in Patients with Chronic Gastric Dyspepsia

Abstract Background One of the most prevalent, severe, and sneaky chronic disorders in people is chronic gastritis. Numerous hundreds of millions of individuals worldwide may have chronic gastritis in one way or another, according to estimates that more than half of the world's population has this disease to some degree or extent. Despite the clear role of gastritis in the etiology of common peptic ulcers and stomach malignancies, the relevance of chronic gastritis as a dangerous disease is vastly overestimated in clinical practice. Aim of the Work to compare the endoscopic diagnosis and histopathologic diagnosis of pan gastritis in patients presented with chronic gastric dyspepsia. Patients and Methods This study is a Randomized study conducted at Gastroenterology Medicine outpatient clinic and endoscopy unit in Air Force General Hospital and Benha teaching hospital included 100 patients presented by dyspepsia for more than 8 weeks Results In this study we demonstrated that RBCs ranged from 3.8 to 5.9 x1012/L with a mean ± SD of 4.86 ± 0.64 x1012/L. WBCs ranged from 4 to 9.5 x109/L with a mean ± SD of 6.62 ± 1.55 x109/L. Platelets ranged from 120 to 348 x103/µL with a mean ± SD of 224.71 ± 63.94 x103/µL. Hb ranged from 9.5 to 14.5 g/dL with a mean ± SD of 11.83 ± 1.55 g/dL. ALT ranged from 5.9 to 45 U/L with a mean ± SD of 24.34 ± 11.46 U/L. AST ranged from 10.7 to 49 U/L with a mean ± SD of 29.28 ± 10.33 U/L. Urea ranged from 6.5 to 44.7 mg/dL with a mean ± SD of 24.77 ± 10.39 mg/dL. Creatinine ranged from 0.2 to 2.1 mg/dL with a mean ± SD of 1.1 ± 0.6 mg/dL. In this study we illustrated that regarding endoscopic results, 25 (25%) patients were normal, 56 (56%) had gastritis and 19 (19%) had other lesions. regarding patients with gastritis, 7 (12.5%) of them had atrophy, 8 (14.29%) had mucosal nodularity, 24 (42.86%) had edema and 17 (30.36%) had erythema while the location of gastritis varied as 41 (73.21%) patients had pan-gastritis, 9 (16.07%) had antrum predominant gastritis and 6 (10.71%) had corpus predominant gastritis. regarding patients with other lesions, 7 (36.84%) of them had esophagitis, 9 (47.37%) had duodenal ulcer and 3 (15.79%) had hiatal hernia. In this study we illustrated that there was a statistically significant difference among endoscopic and histopathological findings of the studied patients (P value <0.001). Conclusion Pan-gastritis is a common finding in early dyspeptic patients and endoscopy has high sensitivity in diagnosis of pangastritis and normal endoscopic appearance did not rule it out, and the histopathology was still the gold standard method.