Comparative Study of Epidemiology of HCC in the (HCV) Patients in the Egyptian Population before and after Hepatitis C National Screening Program (100 Million Seha)

Abstract Background HCC is considerd one of the most common tumors in Egypt and one of the most common predisposing factors is HCV Objectives The aim of this study is to determine the clinical characteristics and relevance between HCC patients before and after national screening of HCV (two groups) according to child score, stage of disease, effect of treatment at clinical oncology department of Ain Shams University, Cairo, Egypt Subjects and Methods This retrospective analytical study included HCC patients (pathologically confirmed or diagnosed by radiological criteria) from Clinical Oncology Department, Ain Shams University Faculty of Medicine, Cairo, Egypt. from January 2017 to December 2020. and stratified into two groups 1stgroup was for patients who were diagnosed as HCC 2 years before national screening program of HCV (100 million seha), 2nd group was for patients who presented after national screening program Results In Group (1) most of the patients were diagnosed as HCV (86) patients (97.7%) of the patients with Co HBV infection (4) patients (4.2%), in Group (2) most of the patients were diagnosed as HCV (92) patients declined to (82.1%) while Co HBV declined to (1) patient (1%), number of patients who had Child A classification in Group (1) (36) patients and Child C (7) patients (10.9%), in Group (2) number of the patients who were Child A (62) patients (69.7%), Child C (3) patients (3.4%), in Group (1) number of patients who were ECOG PS 1 (26) patients (41.3%) while ECOG PS 4 were (4) patients (6.3%), On the other hand in Group 2 number of the patients who had ECOG PS1 (46) patients (46.5%) while ECOG PS 4 declined to (2) patients (2%), According to (BCLC) in Group 1, number of the patients with BCLC (C), (56) patients (63.6%), BCLC (A) were only (10) patients (11.4%) of the patients, BCLC (D) (5) patients (5.7%), in Group (2), BCLC (C) (62) patients declined to (54.4%), BCLC (A) increased to (32) patients (28.1%), BCLC (D) (3) patients (2.6%) of the total patients in Group 2. Conclusion our study demonstarted the efficacy of national screening program of HCV in the screening, diagnosis and treatment of HCC, we conducted that the results of the screening program could affect the diagnosis and treatment of HCC so its very considrable that discovery of HCC in earlier Child classification, Stage after national screening affected the treatment.