Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling
Elabela plays a crucial role in protecting against vascular cuproptosis and arterial calcification by activating the PPAR-γ /FDX1 signaling. Elabela supplementation and cuproptosis suppression serve as effective therapeutic approaches for managing vascular calcification and related cardiovascular disorders.
Authors
- Jing Cheng (ORCID: https://orcid.org/0000-0002-4100-5567)
- Kaixin Yan (ORCID: https://orcid.org/0009-0004-9430-0975)
- Jiuchang Zhong (ORCID: https://orcid.org/0000-0002-2315-3515)
- Xiaoyan Liu (ORCID: https://orcid.org/0000-0002-1732-5923)
- Jing Li (ORCID: https://orcid.org/0000-0002-5102-4315)
- Yufei Chen
- Siyuan Wang (ORCID: https://orcid.org/0000-0001-6792-7482)
- Ying Liu (ORCID: https://orcid.org/0000-0002-9246-8676)
- Yihang Chen
- Jiawei Song (ORCID: https://orcid.org/0009-0006-7338-8917)
- Rui-Qiang Qi
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s10020-024-00997-3
- Citations
- 14
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China