Impact of Enteral and Parenteral Nutrition on Mortality and Morbidity of Mechanically Ventilated Severely Septic Critically Ill Patients

Abstract Background Malnutrition is common among critically ill patients and can negatively affect clinical outcomes. Artificial nutrition and hydration support is considered standard care in critical illness. However, there is considerable variation in nutrition support practice in ICUs. Aim of the Work The study aims to investigate the clinical outcomes difference of nutritional support TPN and EN in intubated mechanically ventilated severe septic patients over ICU stay. Patients and Methods The study involves 80 patients, and APATCHE and SOFA scores were used to assess clinical outcomes such as survival rate, extubation rate, tracheostomy, and complications. Results There is no significant difference between TPN and EN in terms of delivered Kcal and delivered proteins, APATCHE, and SOFA scores. Clinical outcomes such as survival rate and extubation rates are also not different between both groups. However, there were significantly more digestive complications in the early EN group, indicating that PN may be the safer route in some patient groups. Conclusion The study concludes that there is no difference in mortality and extubation rate between EN and TPN in intubated mechanically ventilated severe septic patients. However, there were significantly more digestive complications in the early EN group, indicating that PN may be the safer route in some patient groups.