Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis
NETs-induced AIM2 inflammasome-dependent pyroptosis in macrophages facilitates liver inflammation/fibrosis progression. The identified NET-AIM2 inflammasome cascade could serve as a novel therapeutic target for hepatic inflammation/fibrosis progression.
Authors
- Yan You (ORCID: https://orcid.org/0000-0002-2564-828X)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-1059-9788)
- Liang Duan (ORCID: https://orcid.org/0000-0002-3882-7527)
- Rui Wu (ORCID: https://orcid.org/0000-0003-0110-4912)
- Xi Zhan (ORCID: https://orcid.org/0000-0002-6979-1379)
- Xuanyi Wang (ORCID: https://orcid.org/0000-0001-6398-9184)
- Yunyuan Zhang (ORCID: https://orcid.org/0000-0003-1429-6183)
- Xiang Lin (ORCID: https://orcid.org/0009-0003-5331-8872)
- Jianbo Zhang (ORCID: https://orcid.org/0000-0002-8177-6817)
- Yaqian Duan
- Rong Wu (ORCID: https://orcid.org/0000-0002-1772-2339)
Institutions
- Qingdao University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Affiliated Hospital of Qingdao University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s12964-024-01944-9
- Citations
- 20
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment