Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF/PI3K/AKT pathway
Our findings reveal that the suppression of lncRNA-VSIG2-1:1 expression stimulates angiogenesis in vitro by inducing the initiation of the VEGF/PI3K/AKT signaling pathway. This observation may aid the development of novel therapeutic targets for treating BPD.
Authors
- Chao Wen (ORCID: https://orcid.org/0000-0002-8083-5651)
- Zhenlang Lin (ORCID: https://orcid.org/0000-0001-7319-6049)
- Shangqin Chen (ORCID: https://orcid.org/0000-0003-4917-0521)
- Yihui Zheng (ORCID: https://orcid.org/0000-0003-0521-9389)
- Zhongjie Liang (ORCID: https://orcid.org/0000-0003-0763-5407)
- Jing Lin (ORCID: https://orcid.org/0000-0002-7162-3630)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Mingchu Fang (ORCID: https://orcid.org/0000-0002-1843-3547)
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Zhejiang Institute of Communications (CN)
- Zhejiang Lab (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s12931-024-03039-y
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau