Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls
The gout risk allele G associates with lower circulating IL-1Ra, lower IL-1Ra production in PBMC assays and elevated IL-1β production in PBMCs challenged with C16 + MSU crystals but not in unchallenged cells. Our data indicate that the genetic signal that associates with gout at IL1RN-IL1F10 region functions to alter expression of IL-1Ra when stimulated by MSU crystals.
Authors
- Orsolya I. Gaal (ORCID: https://orcid.org/0000-0002-4726-915X)
- Tania O. Crișan (ORCID: https://orcid.org/0000-0002-3282-5627)
- Tony Raymond Merriman (ORCID: https://orcid.org/0000-0003-0844-8726)
- Valentin Nica (ORCID: https://orcid.org/0009-0005-3269-3985)
- Cristina Pamfil (ORCID: https://orcid.org/0000-0003-0175-2645)
- Leo A. B. Joosten (ORCID: https://orcid.org/0000-0001-6166-9830)
- Simona Rednic (ORCID: https://orcid.org/0000-0001-8149-7722)
- Georgiana Cabău (ORCID: https://orcid.org/0000-0001-8914-2352)
- Megan Leask (ORCID: https://orcid.org/0000-0003-3199-5277)
- Dennis M. de Graaf (ORCID: https://orcid.org/0000-0002-9198-7159)
- Medeea Badii (ORCID: https://orcid.org/0000-0002-1185-8729)
- Ioana Hotea (ORCID: https://orcid.org/0000-0003-2552-9835)
- Li Yang (ORCID: https://orcid.org/0000-0002-9337-1382)
- Zhenhua Zhang (ORCID: https://orcid.org/0000-0003-2714-0540)
Institutions
- University of Bonn (DE)
- Radboud University Nijmegen (NL)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca (RO)
- Radboud University Medical Center (NL)
- University of Alabama at Birmingham (US)
- Medizinische Hochschule Hannover (DE)
- Helmholtz Centre for Infection Research (DE)
- Centre for Individualised Infection Medicine (DE)
- Center for Experimental and Clinical Infection Research (DE)
- University of Otago (NZ)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s13075-024-03436-0
- Citations
- 3
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.02