Adipose stem cell exosomes, stimulated by pro-inflammatory factors, enhance immune evasion in triple-negative breast cancer by modulating the HDAC6/STAT3/PD-L1 pathway through the transporter UCHL1
Pro-inflammatory factors (IFN-γ + TNF-α) stimulating ADSCs-Exos enhance immune evasion in triple-negative breast cancer by regulating the HDAC6/STAT3/PD-L1 pathway via UCHL1 transporter. Thus, UCHL1 inhibition may enhance the response of TNBC to immunotherapy.
Authors
- Yukun Cao (ORCID: https://orcid.org/0000-0002-8391-841X)
- Ke‐Jing Zhang (ORCID: https://orcid.org/0000-0002-8143-012X)
- Yiguo Hu (ORCID: https://orcid.org/0000-0002-3973-2140)
- Qin Zhu (ORCID: https://orcid.org/0000-0002-9864-5434)
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s12935-024-03557-1
- Citations
- 6
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Natural Science Foundation of Hainan Province