The Incidence of Breast Cancer in Egyptian Females in Correlation to Different Mammographic ACR Densities

Abstract Background Breast density, radiologically, referred as fibro glandular mammary tissue, was found to be a predisposing factor for breast cancer (BC). However, the stated degree of elevated BC risk varies widely in the literature. Objective To detect the relationship between different breast mammographic densities and risk for BC in Egyptian females. Patients and Methods An analytical cross-sectional prospective study was conducted at Ain Shams University Hospital, National Project for Women Health and Private Centre in the period from December 2020 to December 2021. The study was applied to 814 asymptomatic females above 35 years old who came for BC screening using full-field digital mammography. Results The incidence of BC was found in 84 females (10.3%). The BC incidence in females with ACR-A was 6.3%, ACR-B was 8.5%, ACR-C was 16.3% and ACR-D was 27.8%, with a p- value (p < 0.001). Using logistic regression analysis showed that three types of breast densities increased the risk of BC, where patients with type-B, type-C, and type-D breast density had a 1.39, 2.92, and 3.12 times more risk for BC, respectively (p value= 0.010, 0.003, and 0.036 respectively). Conclusion Among Egyptian females, the incidence of BC is 10.3%. Our data revealed that the more breast density, the higher the incidence of BC, and affirmed that breast density is a risk factor for BC development.