Targeting <i>SLC7A11</i> /xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti‐tumor immune response
After RFA treatment in patients with liver cancer, the expression of <i>SLC7A11</i>/xCT and the proportion of DCs in the TME were significantly increased. <i>SLC7A11</i>/xCT is a poor prognostic marker for liver cancer and is mainly expressed in DCs in the TME. Targeting xCT in DCs combined with RFA significantly enhances anti-tumor immunity, suppressing tumor growth and offering a promising strategy for improved therapeutic outcomes in liver cancer.
Authors
- Yiting Sun (ORCID: https://orcid.org/0000-0001-6196-1727)
- Bufu Tang (ORCID: https://orcid.org/0000-0003-3525-4433)
- Zhao Huang (ORCID: https://orcid.org/0000-0002-1151-4942)
- Yuzhao Jin
- Zhiyong Xu (ORCID: https://orcid.org/0000-0001-9873-8617)
- Yueli Shi (ORCID: https://orcid.org/0000-0002-0669-6665)
- Songhua Cai (ORCID: https://orcid.org/0000-0003-3839-2030)
- Peng Luo (ORCID: https://orcid.org/0000-0002-8215-2045)
- Wangting Xu
- Yuzhen Zeng
- Yang Zhou (ORCID: https://orcid.org/0000-0003-4160-0646)
- Dandan Guo (ORCID: https://orcid.org/0000-0002-3324-5851)
- Zaoqu Liu (ORCID: https://orcid.org/0000-0002-0452-742X)
Institutions
- Sun Yat-sen University (CN)
- Dalian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Zhujiang Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- Zhejiang University (CN)
- China Medical University (CN)
Publication Details
- Journal
- iMeta
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1002/imt2.248
- Citations
- 15
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 6.04
Funders
- National Natural Science Foundation of China